解剖学和形态学
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听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
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神经系统科学
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产科医学和妇科医学
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整形外科学
耳鼻喉科学
病理学
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药理学和药剂学
生理学
基本医疗保健
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健康政策和服务
心理学,临床
abstract::In vitro incubations of CD4+ T cells with anti-CD4 monoclonal antibody (Mab) demonstrated saturation binding and inhibited both PPD-stimulated proliferation and delayed-type hypersensitivity (DTH) after passive transfer of these cells into naive rats. In comparison, in vivo administration of anti-CD4 Mab into rats, 2 ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1104
更新日期:1995-06-01 00:00:00
abstract::The effects of oral administration of methylated bovine serum albumin (mBSA) on antigen-induced arthritis (AIA) in rats that was induced by immunization with mBSA followed by the intraarticular injection of the same antigen were investigated. When mBSA was orally given to animals before immunization with the antigen, ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1098
更新日期:1995-06-01 00:00:00
abstract::The anti-spirochete T cell immune response to immunization with Borrelia burgdorferi was investigated. The cellular immune response to vaccination of immunocompetent BALB/c mice was characterized initially in vitro by assay of the proliferative response of primary lymph node cells to B. burgdorferi sonicate. Subsequen...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1073
更新日期:1995-05-01 00:00:00
abstract::Poxviruses are a large, complex group of highly successful pathogens that cause disease in humans and other animals. They encode several proteins postulated to be involved in the evasion of host immunity and therefore serve as excellent models for understanding virus-host interaction during the early stages of viral i...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1086
更新日期:1995-05-01 00:00:00
abstract::Staphylococcus enterotoxins bind class II MHC molecules on antigen-presenting cells (APC) and stimulate T cells expressing appropriate V beta gene products. Although the role of non-TcR-associated costimulatory receptors during antigen-specific T cell stimulation has been clearly established, the involvement of costim...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1084
更新日期:1995-05-01 00:00:00
abstract::The pim-1 gene encodes a serine/threonine protein kinase with expression restricted primarily to cells of hematopoietic lineage and is thought to play a role in the signal transduction events associated with lymphocyte activation. A rapid increase in pim-1 mRNA levels was found after stimulation of normal unseparated ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1059
更新日期:1995-04-15 00:00:00
abstract::We have previously described a novel human B cell differentiation factor (BCDF), 446-BCDF, that is distinct biochemically and functionally from other cytokines. Since signal transduction pathways involved in human B cell differentiation have been incompletely studied and are poorly understood, we assessed the effects ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1050
更新日期:1995-04-15 00:00:00
abstract::Recently we have shown that the generation of IFN-gamma-producing cells (IFN-gamma pc) were severely suppressed in cultures of Con A-stimulated splenocytes obtained from HgCl2-exposed BN but not Lewis rats. Since BN rats develop a TH2-biased polyclonal autoimmune syndrome upon exposure to HgCl2, whereas Lewis rats exh...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1027
更新日期:1995-04-01 00:00:00
abstract::We previously reported the amino acid sequence of the human macrophage chemotactic factor with a molecular weight of 1000 (MCF-1) was WLGREDGSE. In this study we examined the roles of MCF-1 and tumor necrosis factor (TNF) in a guinea pig delayed-type hypersensitivity (DTH) reaction. When macrophage chemotactic activit...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1038
更新日期:1995-04-01 00:00:00
abstract::pp125FAK is a novel protein tyrosine kinase associated with focal adhesions. It has been shown that ligation of VLA beta 1 integrins on a number of cell types enhanced tyrosine phosphorylation and kinase activity of pp125FAK. Cellular transformation by retroviral oncogene products or mitogenic neuropeptides also resul...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1002
更新日期:1995-03-01 00:00:00
abstract::The aim of our work was to study apoptosis as a possible mechanism of CD4+ lymphocyte depletion in AIDS patients and to test whether IL-12 could limit this phenomenon. As an in vitro model, we used a human IL-2-dependent Th1 clone from an uninfected individual. We found that CD4 cross-linking, obtained either by mouse...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1003
更新日期:1995-03-01 00:00:00
abstract::Extracellular adenine nucleotides are inhibitors of the human natural killer cell line NK3.3 natural cytotoxicity activity. Natural cytotoxicity was inhibited approximately 26% by 1 mM ATP and 21% by 1 mM ADP. 5'-Adenylyl imidodiphosphate, a nonhydrolyzable ATP analog, inhibited natural cytotoxicity by 41% at a concen...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(95)80028-h
更新日期:1995-02-01 00:00:00
abstract::Recently, it has been reported that IL-4 production by murine Th2 cell lines is insensitive to inhibition by E-type prostaglandins. In the present study, IL-4 production in vitro by freshly isolated concanavalin A (Con A)-stimulated murine spleen cells was readily suppressed by PGE2 with an I50 of 2 nM. Comparable sup...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(95)80039-l
更新日期:1995-02-01 00:00:00
abstract::Apolipoprotein E (apoE), a lipid transport protein important in cholesterol homeostasis, inhibits the proliferation of interleukin-dependent lymphocytes. Growth factor-responsive cells are blocked in the G1A phase of the cell cycle. Suppression by apoE is independent of growth factor, as evidenced by the fact that int...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(95)80004-3
更新日期:1995-01-01 00:00:00
abstract::This study examined the characteristics of functional anergy of natural killer cells (NK) following their interaction with target cells. Purified NK cells were cocultured with K562 for 15 min or 4 hr to allow for binding of targets to NK cells. The resulting NK-target conjugates were then dissociated by EDTA, and the ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(95)80013-9
更新日期:1995-01-01 00:00:00
abstract::We investigated the role of IL-12 in regulating IL-2 and IFN-gamma production in primary culture of human T cells. Addition of neutralizing antiserum against the 40-kDa subunit of IL-12 to PHA-stimulated PBMC markedly reduced both IFN-gamma protein production and mRNA accumulation and stability. Moreover, concurrent t...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1303
更新日期:1994-12-01 00:00:00
abstract::The development of B cell tolerance is believed to involve negative signaling to B cells derived from the binding of antigen to the B cell surface immunoglobulin. B cell lines that receive negative signals may provide useful models for studying the mechanisms of B cell tolerance. We have established a human B lymphoma...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1314
更新日期:1994-12-01 00:00:00
abstract::Human melanoma tumor cells were genetically modified in vitro by transferring the interleukin-2 (IL-2) gene via a retroviral vector into established or fresh tumor cells. In addition, human melanoma cells were transduced in vivo by the direct injection of the IL-2/retroviral vector into melanoma xenografts in nude mic...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1292
更新日期:1994-11-01 00:00:00
abstract::Development of contact hypersensitivity in mice depends on the migration of Langerhans cells from the epidermis to regional lymph nodes. Since ICAM-1 and LFA-1 play important roles in leukocyte migration, we sought to determine whether in vivo administration of anti-ICAM-1 and anti-LFA-1 antibodies would inhibit conta...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1285
更新日期:1994-10-15 00:00:00
abstract::Antigen-specific signal transduction leading to IL2 induction and secretion in the T cell line 171 is augmented by association of p56lck with CD4. Although no change in cytoplasmic calcium level ([Ca2+]i) was detectable during antigen-specific signal transduction of 171-CD4+ cells, IL2 induction was inhibited by FK506...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1255
更新日期:1994-10-01 00:00:00
abstract::Estrogen displays potent immunoregulatory properties. In the present study we investigated the in vivo effect of estrogen on natural killer (NK) cell cytotoxic activity in several mouse strains. After castration, 17 beta-estradiol was administered in low or high doses. After 3-6 weeks of hormone administration an in v...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1262
更新日期:1994-10-01 00:00:00
abstract::The mechanisms of glucocorticoid-induced immunosuppression of human monocytes for the defense of Candida albicans were examined in this in vitro study. Dexamethasone at pharmacological concentrations (10(-7)-10(-5) M) dose-dependently attenuated growth inhibition of C. albicans by resident monocytes. In interferon-gam...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1230
更新日期:1994-09-01 00:00:00
abstract::Previous investigations have demonstrated a strain-associated differential susceptibility to herpes simplex virus-1 (HSV-1) infection in mice; C57BL/6 mice are more resistant to infection than BALB/c mice. Despite considerable research dealing with the immune response to HSV-1, relatively little attention has been pai...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1246
更新日期:1994-09-01 00:00:00
abstract::The antifungal activity of nonactivated resident murine peritoneal macrophages for Cryptococcus neoformans was studied. Macrophages from five of six mouse strains tested had significant (40 to 80%) fungistatic activity, depending on the inoculum size, in a 24-hr coculture system. Macrophages from two outbred (SW and I...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1200
更新日期:1994-08-01 00:00:00
abstract::Prior studies have shown that intraperitoneal (ip) injection of 25 IU of human rIL-2 can effectively modulate in vivo immune reactivity to thymus-dependent and thymus-independent type 2 immunogens in Xenopus laevis, the South African clawed toad, but is less successful at affecting toad cells in vitro. Here we compare...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1224
更新日期:1994-08-01 00:00:00
abstract::Several lines of evidence suggest that nitric oxide (NO), generated through nitric oxide synthase (NOS) by cleavage of terminal guanidino nitrogen from L-arginine, mediates tumor cell killing by mononuclear phagocytes. Natural killer (NK) cells are cytotoxic effector cells that lyse a variety of tumor and virus-infect...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1215
更新日期:1994-08-01 00:00:00
abstract::To investigate the process of tolerance induction we have developed an in vivo model using TCR beta-chain transgenic mice tolerized with the superantigen staphylococcal enterotoxin B. We have previously demonstrated that tolerized peripheral T cells were anergic when stimulated in vitro with immunogenic peptides, supe...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1177
更新日期:1994-07-01 00:00:00
abstract::Mice homozygous for either the generalized lymphoproliferative disease (gld) or the lymphoproliferation (lpr) nonallelic mutations develop similar syndromes combining systemic autoimmunity and lymphoproliferative disease. Though essentially recessive, the lpr and gld mutations may be expressed in the heterozygous stat...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1195
更新日期:1994-07-01 00:00:00
abstract::We tested the impact of interleukin-12 (IL-12) and of cytotoxic leukocytes (particularly natural killer (NK) cells) from normal and HIV-1-infected subjects on lysis of human monocytes infected with Mycobacterium tuberculosis. Nylon wool nonadherent cells stimulated with interleukin-2 (IL-2) or with IL-12 developed sig...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1196
更新日期:1994-07-01 00:00:00
abstract::Experimental autoimmune neuritis (EAN) is a T-cell-mediated autoimmune disease characterized by demyelination and mononuclear cell infiltration of the peripheral nervous system. It is induced in Lewis rats by administration of myelin P2 protein or a synthetic peptide (SP-26) corresponding to amino acid residues 53-78 ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1156
更新日期:1994-06-01 00:00:00
abstract::Interleukin 4 (IL-4)-induced IgE production by normal peripheral blood mononuclear cells (PBMC) and E- cells (PBMC partially depleted of T cells) was significantly enhanced by leukotriene B4(LTB4) in a dose-dependent manner, whereas LTB4 by itself was not effective for IgE production. The potentiating effect of LTB4 w...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1158
更新日期:1994-06-01 00:00:00
abstract::The skin and draining lymph nodes of BALB/c mice were examined for IFN-gamma, IL-2, and IL-4 mRNA expression by in situ hybridization in three successive infestations with nymphal Ixodes ricinus ticks. IFN-gamma and IL-2 mRNA positive cells were readily detected in lymph node sections during primary antigenic stimulat...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1170
更新日期:1994-06-01 00:00:00
abstract::Bcl-2 proto-oncogene is expressed in normal lymphoid tissues and its role has been suggested to involve the selection of B and T cells. Here we report three-color flow cytometric studies on the expression of bcl-2 protein in the thymus and periphery. Bcl-2 was expressed in the majority of T and B cells and down-regula...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1127
更新日期:1994-05-01 00:00:00
abstract::We have established a long-lasting heart allograft tolerance in H-2-incompatible combinations by intravenous injection of 10(8) allogeneic spleen cells followed by the administration of 200 mg/kg of cyclophosphamide (CP). When C57BL/10 mice (B10, H-2b) were primed iv with 1 x 10(8) viable spleen cells from naive BALB/...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1142
更新日期:1994-05-01 00:00:00
abstract::We have investigated the ability of interleukin-10 (IL-10) to modulate murine intrathymic T cell differentiation using a fetal thymic organ culture (FTOC) model. Addition of as little as 11 ng of recombinant murine IL-10 (mIL-10) per day produced a significant increase in the proportion and number of gamma delta-TCR+ ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1105
更新日期:1994-04-15 00:00:00
abstract::We previously showed that DT-5461a, a lipid A analog, has antitumor activity and relatively low toxicity in animals. To clarify its immunostimulatory effect we have studied the cytokine inducibility of DT-5461a and the mechanism involved in the cytokine expression in macrophages. While the activity is lower than that ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1100
更新日期:1994-04-15 00:00:00
abstract::TJ6 is a novel protein which has immunosuppressive activity and may have a functional role in fetal allograft survival during pregnancy. Initial studies indicated that when mice were treated with an anti-TJ6 binding mAb early in pregnancy, the pregnancies were completely ablated and that TJ6 expression is enhanced dra...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1114
更新日期:1994-04-15 00:00:00
abstract::The in vivo and in vitro accessory cell requirements of class I major histocompatability complex (MHC) antigen-restricted cytotoxic T-lymphocyte (CTL) responses were determined using cell-depletion experiments coupled with active immunizations using ovalbumin (OVA) as the immunogen and saponin adjuvant (QS-21). To par...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1086
更新日期:1994-04-01 00:00:00
abstract::Hen egg white lysozyme (HEL)-specific T cell lines and clones were generated from B6 and BDF1 mice. A variety of clonotypes were found among clones generated at an early stage (1 month) whereas fewer clonotypes were detected after several weeks of culture. Furthermore, a bulk line switched from its initial fine peptid...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1088
更新日期:1994-04-01 00:00:00
abstract::The allogeneic mixed lymphocyte reaction (MLR) is regarded as an effective model for examining the events which occur during an allospecific immune response. Numerous studies have delineated the role of adherence molecule interactions during the MLR response. In the present study we have identified VCAM-1 as having a ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1059
更新日期:1994-03-01 00:00:00